International Chemical Safety Cards para-TOLUIDINE ICSC: 0343 para-TOLUIDINE 4-Amino-1-methylbenzene 4-Aminotoluene p-Methylaniline C7H9N/C6H4CH3NH2 Molecular mass: 107.2 CAS # 106-49-0 RTECS # XU3150000 ICSC # 0343 UN # 1708 EC # 612-024-00-4 TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. NO contact with nitric acid. Powder, AFFF, foam, carbon dioxide. EXPLOSION Above 86°C explosive vapour/air mixtures may be formed. Above 86°C use a closed system, ventilation. In case of fire: keep drums, etc., cool by spraying with water. EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR! INHALATION Blue lips or finger nails. Blue skin. Confusion. Dizziness. Headache. Laboured breathing. Nausea. Shortness of breath. Unconsciousness. Weakness. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration if indicated. Refer for medical attention. SKIN MAY BE ABSORBED! Redness. Blue lips or fingernails. Blue skin (further see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. EYES Redness. Pain. Severe deep burns. Safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION Blue lips or fingernails. Blue skin. Dizziness. Headache. Laboured breathing (further see Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable container. Carefully collect remainder, then remove to safe place (extra personal protection: complete protective clothing including self-contained breathing apparatus). Separated from strong oxidants, strong acids, food and feedstuffs. Cool. Dry. Well closed. Ventilation along the floor. Do not transport with food and feedstuffs. T symbol R: 23/24/25-33 S: (1/2-)28-36/37-45 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0343 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993 No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and IDLH values.

International Chemical Safety Cards para-TOLUIDINE ICSC: 0343 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS FLAKES , TURNS DARK ON EXPOSURE TO AIR AND LIGHT. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating or on burning producing toxic fumes including nitrogen oxides. Reacts violently with oxidants, especially nitric acid. OCCUPATIONAL EXPOSURE LIMITS (OELs): TLV: 2 ppm; 8.8 mg/m3 (as TWA) A2 (skin) (ACGIH 1994-1995). OSHA PEL: none NIOSH REL: Ca See Appendix A NIOSH IDLH: Potential occupational carcinogen No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes and the skin. The substance may cause effects on the blood, bladder and kidneys , resulting in tissue lesions and formation of methaemoglobin. Exposure to high concentrations may result in damage to kidneys and bladder. The effects may be delayed. Medical observation is indicated. See Notes. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood , resulting in formation of methaemoglobin (see Notes). PHYSICAL PROPERTIES Boiling point: 200°C Melting point: 44-45°C Relative density (water = 1): 1.05 Solubility in water: poor Vapour pressure, kPa at 42°C: 0.13 Relative vapour density (air = 1): 3.9 Flash point: 86-87°C c.c. Auto-ignition temperature: 482°C Explosive limits, vol% in air: 1.1-6.6 Octanol/water partition coefficient as log Pow: 1.39 ENVIRONMENTAL DATA N O T E S Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home. Also consult ICSC # 0341, ortho-Toluidine and 0342, meta-Toluidine. Transport Emergency Card: TEC (R)-61G12b NFPA Code: H3; F2; R0 ADDITIONAL INFORMATION ICSC: 0343 para-TOLUIDINE © IPCS, CEC, 1993

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and IDLH values.