International Chemical Safety Cards NICOTINE ICSC: 0519 NICOTINE (S)-3-(1-Methylpyrrolidin-2-yl)pyridine 3-(1-Methyl-2-pyrrolidinyl)pyridine beta-Pyridyl-alpha-N-methylpyrrolidine 1-Methyl-2-(3-pyridyl)pyrrolidine C10H14N2 Molecular mass: 162.2 CAS # 54-11-5 RTECS # QS5250000 ICSC # 0519 UN # 1654 EC # 614-001-00-4 TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, alcohol-resistant foam, water spray, carbon dioxide. EXPLOSION Above 95°C explosive vapour/air mixtures may be formed. Above 95°C use a closed system, ventilation. EXPOSURE PREVENT GENERATION OF MISTS! AVOID EXPOSURE OF (PREGNANT) WOMEN! IN ALL CASES CONSULT A DOCTOR! INHALATION Burning sensation. Nausea. Vomiting. Convulsions. Abdominal pain. Diarrhoea. Headache. Sweating. Weakness. Dizziness. Confusion. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention. SKIN MAY BE ABSORBED! Redness. Burning sensation (see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. EYES Pain. Redness. Safety goggles, face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION (see Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer (extra personal protection: complete protective clothing including self-contained breathing apparatus). Provision to contain effluent from fire extinguishing. Separated from strong oxidants, food and feedstuffs. Dry. Ventilation along the floor. Do not transport with food and feedstuffs. T+ symbol R: 25-27 S: (1/2-)36/37-45 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0519 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993 No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and IDLH values.

International Chemical Safety Cards NICOTINE ICSC: 0519 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: OILY, COLOURLESS HYGROSCOPIC LIQUID , WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic fumes including nitrogen oxides and carbon monoxide. Reacts violently with strong oxidants. OCCUPATIONAL EXPOSURE LIMITS (OELs): TLV: 0.5 mg/m3 (as TWA) (skin) (ACGIH 1996). MAK: 0.07 ppm; 0.5 mg/m3; H (1996). OSHA PEL: TWA 0.5 mg/m3 skin NIOSH REL: TWA 0.5 mg/m3 skin NIOSH IDLH: 5 mg/m3 ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and through the skin, and by ingestion. INHALATION RISK: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes and the skin. The substance may cause effects on the cardiovascular system and central nervous system , resulting in convulsions and respiratory failure. Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Animal tests show that this substance possibly causes toxic effects upon human reproduction. PHYSICAL PROPERTIES Boiling point (decomposes): 247°C Melting point: -80°C Relative density (water = 1): 1.01 Solubility in water: miscible Vapour pressure, kPa at 20°C: 0.006 Relative vapour density (air = 1): 5.6 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 95°C c.c. Auto-ignition temperature: 240°C Explosive limits, vol% in air: 0.7-4 Octanol/water partition coefficient as log Pow: 1.2 ENVIRONMENTAL DATA The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. N O T E S Destruxol, XL All Insecticide are trade names. Transport Emergency Card: TEC (R)-61G68 NFPA Code: H4; F1; R0; ADDITIONAL INFORMATION ICSC: 0519 NICOTINE © IPCS, CEC, 1993

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and IDLH values.