International Chemical Safety Cards

PROPIONIC ANHYDRIDE ICSC: 0558

PROPIONIC ANHYDRIDE
Propanoic anhydride
Methylacetic anhydride
Propanoic acid anhydride
C6H10O3 / (CH3CH2CO)2O
Molecular mass: 130.2
CAS # 123-62-6
RTECS # UF9100000
ICSC # 0558
UN # 2496
EC # 607-010-00-X
TYPES OF
HAZARD/
EXPOSURE 		ACUTE HAZARDS/
SYMPTOMS 		PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 63°C explosive vapour/air mixtures may be formed.
Above 63°C use a closed system, ventilation.

EXPOSURE
PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!

  • INHALATION
    		• Sore throat. Cough. Burning sensation. Shortness of breath. Symptoms may be delayed (see Notes).
    		Ventilation, local exhaust, or breathing protection.
    		Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.
  • SKIN
    		• Pain. Blisters.
    		Protective gloves. Protective clothing.
    		Remove contaminated clothes. Rinse skin with plenty of water or shower.
  • EYES
    		• Redness. Pain. Severe deep burns.
    		Face shield, or eye protection in combination with breathing protection.
    		First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
  • INGESTION
    		• Burning sensation. Abdominal pain. Shock or collapse. Sore throat.
    		Do not eat, drink, or smoke during work.
    		Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.
    SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
    Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place (extra personal protection: chemical suit including self-contained breathing apparatus).
    		Separated from acids, bases, oxidants, food and feedstuffs. Dry. Ventilation along the floor.
    		Do not transport with food and feedstuffs.
    C symbol
    R: 34
    S: (1/2)-26-45
    UN Hazard Class: 8
    UN Packing Group: III
    SEE IMPORTANT INFORMATION ON BACK
    ICSC: 0558 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993 No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and IDLH values.

    International Chemical Safety Cards

    PROPIONIC ANHYDRIDE ICSC: 0558

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    PHYSICAL STATE; APPEARANCE:
     COLOURLESS LIQUID , WITH PUNGENT ODOUR.

    PHYSICAL DANGERS:
     The vapour is heavier than air.

    CHEMICAL DANGERS:
     The substance decomposes on contact with water producing corrosive propionic acid. Reacts violently with acids, bases and oxidants causing fire and explosion hazard.

    OCCUPATIONAL EXPOSURE LIMITS (OELs):
     TLV not established.


    		ROUTES OF EXPOSURE:
     The substance can be absorbed into the body by inhalation of its vapour or its aerosol, and by ingestion.

    INHALATION RISK:
     No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C.

    EFFECTS OF SHORT-TERM EXPOSURE:
     Corrosive. The substance is corrosive to the eyes, the skin and the respiratory tract. Inhalation of vapour or aerosol may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated.

    EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
    PHYSICAL
    PROPERTIES
    Boiling point: 167°C
    Melting point: -45°C
    Relative density (water = 1): 1.01
    Solubility in water: reaction
    Vapour pressure, kPa at 20°C: 100
    		 Relative vapour density (air = 1): 4.5
    Relative density of the vapour/air-mixture at 20°C (air = 1): 4.4
    Flash point: 63°C
    Auto-ignition temperature: 285°C
    Explosive limits, vol% in air: 1.3-9.5
    ENVIRONMENTAL
    DATA
    N O T E S
    The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
    Transport Emergency Card: TEC (R)-80G20
    NFPA Code: H3; F2; R1;
    ADDITIONAL INFORMATION


    ICSC: 0558 PROPIONIC ANHYDRIDE
    © IPCS, CEC, 1993
    IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and IDLH values.