International Chemical Safety Cards THIOMETON ICSC: 0580 THIOMETON S-2-Ethylthioethyl O,O-dimethyl phosphorodithioate Phosphorodithioic acid, S-(2-(ethylthio)ethyl)O,O-dimethyl ester Dithiomethon C6H15O2PS3 / (CH3O)2P(S)SCH2CH2SCH2CH3 Molecular mass: 246.3 CAS # 640-15-3 RTECS # TE4375000 ICSC # 0580 UN # 3018 EC # 015-050-00-9 TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION Risk of fire and explosion if formulations contain flammable/explosive solvents. EXPOSURE PREVENT GENERATION OF MISTS! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR! INHALATION Dizziness. Sweating. Laboured breathing. Nausea. Pupillary constriction, muscle cramp, excessive salivation. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention. SKIN MAY BE ABSORBED! (further see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. EYES Safety spectacles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION Abdominal cramps. Vomiting. Diarrhoea. Weakness. Twitching. Convulsions. Unconsciousness (further see Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer (extra personal protection: chemical protection suit including self-contained breathing apparatus). Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Keep in a well-ventilated room. Do not transport with food and feedstuffs. T symbol R: 21-25 S: (1/2-)36/37-45 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 0580 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993 No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and IDLH values.

International Chemical Safety Cards THIOMETON ICSC: 0580 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS OILY LIQUID , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating or on burning producing toxic fumes including phosphorous oxides, sulfur oxides. OCCUPATIONAL EXPOSURE LIMITS (OELs): TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the nervous system. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact with skin may cause dermatitis. Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms. PHYSICAL PROPERTIES Boiling point at O.013 kPa: 110°C Relative density (water = 1): 1.2 Solubility in water, g/100 ml at 25°C: 0.02 Vapour pressure, Pa at 20°C: 0.02 Relative vapour density (air = 1): 8.5 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Octanol/water partition coefficient as log Pow: 0.51 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to bees. Avoid release to the environment in circumstances different to normal use. N O T E S Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s). Carrier solvents used in commercial formulations may change physical and toxicological properties. Ekatin, Medrin, Unimeton are trade names. Transport Emergency Card: TEC (R)-61G43c ADDITIONAL INFORMATION ICSC: 0580 THIOMETON © IPCS, CEC, 1993

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and IDLH values.