International Chemical Safety Cards

WARFARIN ICSC: 0821

WARFARIN
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
C19H16O4
Molecular mass:
CAS # 81-81-2
RTECS # GN4550000
ICSC # 0821
UN # 3027 (Coumarin derivative pesticides)
EC # 607-056-00-0
TYPES OF
HAZARD/
EXPOSURE 		ACUTE HAZARDS/
SYMPTOMS 		PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible.
NO open flames. NO contact with strong oxidizers.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.

EXPOSURE
PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF (PREGNANT) WOMEN!

  • INHALATION
    		• (see Ingestion).
    		Ventilation, local exhaust, or breathing protection.
    		Fresh air, rest. Refer for medical attention.
  • SKIN
    		• MAY BE ABSORBED!
    		Protective gloves.
    		Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
  • EYES

    		• Face shield or eye protection in combination with breathing protection.
    		First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
  • INGESTION
    		• Bleeding, pinpoint purplish-red spots, bleeding on the skin (see Notes).
    		Do not eat, drink, or smoke during work.
    		Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
    SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
    Sweep spilled substance into sealable containers. Carefully collect remainder, then remove to safe place (extra personal protection: self-contained breathing apparatus).
    		Provision to contain effluent from fire extinguishing. Separated from strong oxidants, food and feedstuffs. Tightly closed. Keep in a well-ventilated room.
    		Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
    T symbol
    R: 47-48/25
    S: 53-44
    UN Hazard Class: 6.1
    UN Packing Group: I
    SEE IMPORTANT INFORMATION ON BACK
    ICSC: 0821 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993 No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and IDLH values.

    International Chemical Safety Cards

    WARFARIN ICSC: 0821

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    PHYSICAL STATE; APPEARANCE:
     ODOURLESS, TASTELESS, COLOURLESS TO WHITE CRYSTALLINE POWDER.

    PHYSICAL DANGERS:
     Dust explosion possible if in powder or granular form, mixed with air.

    CHEMICAL DANGERS:
     Reacts with strong oxidants causing fire and explosion hazard.

    OCCUPATIONAL EXPOSURE LIMITS (OELs):
     TLV: ppm; 0.1 mg/m3 (as TWA) (ACGIH 1991-1992).
    PDK: 0.001 mg/m3 (USSR 1988).
    OSHA PEL: TWA 0.1 mg/m3
    NIOSH REL: TWA 0.1 mg/m3
    NIOSH IDLH: 100 mg/m3


    		ROUTES OF EXPOSURE:
     The substance can be absorbed into the body by inhalation of its aerosol, through the skin, and by ingestion.

    INHALATION RISK:
     Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.

    EFFECTS OF SHORT-TERM EXPOSURE:
     Exposure at low levels could cause hemorrhage. The effects may be delayed.

    EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
     Does cause serious reproductive toxicity in humans. Animal tests show that this substance possibly causes malformations in human babies.
    PHYSICAL
    PROPERTIES
    Decomposes below boiling point:
    Melting point: 161°C
    Solubility in water: none
    Vapour pressure, Pa at 21.5°C: 9
    Relative vapour density (air = 1): 10.6
    		 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
    Flash point: see Notes°C
    Auto-ignition temperature: see Notes°C
    Explosive limits, vol% in air: see Notes
    Octanol/water partition coefficient as log Pow: 2.52
    ENVIRONMENTAL
    DATA
    NOTES
    Warfarin is usually available commercially as the sodium salt. The physical properties above refer to the pure substance. Temperature of decomposition unknown in literature. Auto-ignition temperature is unknown in literature. The substance is combustible but no flash point is available in literature. Explosive limits are unknown in literature. The symptoms of bleeding do not become manifest until several days later. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Do NOT take working clothes home. Athrombine-K, Brumolin, Compound 42, Coumadin, d-CON, Kumadu, Mar-frin, Maveran, Ratoxin, Temus W, Warf Compound 42, and Warficide are trade names.
    Transport Emergency Card: TEC (R)-61G53b
    ADDITIONAL INFORMATION


    ICSC: 0821 WARFARIN
    © IPCS, CEC, 1993
    IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and IDLH values.